I started Lonesome Road a while ago. Here's some things I need to talk about.
There's no opening slideshow. It gave me the impression that yu're supposed to know everything already. I liked that.
I wasn't expecting him. I'm sooo happy that he's with me. He's my first companion from the main game. The backstory you get really opens up ED-E as a character. It also gives the Fallout 3 Enclave a little character, as well. I also like that the upgrades I've gotten so far are more practical than weapon upgrades.
You might be confused by his precense at first. I know I was, but I still squeed when it said "Talk to ED-E." I can't wait to learn more.
Weapons and Armor
I've just gotten the Red Glare. It uses a new ammo type, rockets, instead of missiles. It's kind of weird seeing an automatic rocket launcher.
The H&H Nail Gun had me the moment I saw it. It fires nails that you find in tool boxes. It just seems like a perfect fit for Fallout.
Anyway, I've gotta go. I'll add more later.