So, what weapon would you say defines your Courier? By that, I mean what weapon do you usually have equipped for everyday run of the mill encounters? For me at least, it's the Q-35 Matter Modulator. Nine times out of ten it's what I go into a fight using.
It depends on which character I'm using. Currently? Grenade launcher (any enemy, any location, any range. It's caused problems ). My favorite playthrough ended up being the one where I specialized in the War Club, though.
I'm weapon agnostic. Whatever serves its tactical purpose at the moment.. or whatever I have ammo for.
My Hands. The Mutilator and The Violator! also yelling ATATTATATTATATATTATATATATATATATA *Breaths* ATATATTATTATATATATTATATATATATATA when I pummel a Deathclaw.
If I can get ammo for it, the automatic rifle. Not as much stopping power per shot as other .308 weapons, but emptying the clip will kill anything in a pinch, which is great for things that like to charge and claw you to death.
The Holorifle. Stack an hp draining effect on top of a high attack power, and you've got a great combo. Plus, it's scoped and if you get all the mods, you'll never have to worry about repairing it again. A Light Shining In The Darkness is great when you need mobility, though.
I love my courier so much, I'm now using the concept for our Shadowrun game. I just took the concept of a energy weapons cowboy. The Impedant Cowboy as he is known. He specializes in the Holorifle. The pump action sort of reminds me of a lever action. Probably the most "western" weapon I can think of.