Another debate I think would be interesting as long as everyone doesn't just vote for one gun. 10mm Pistol Classic Fallout pistol that is very early to get and does fairly good damage especially early on. Advantages: Hefty Clip of 12 +4 with mod, Silence capability, and abundant ammo. Disadvantages: Fragile, Worst Hand-loader ammunition. .44 Magnum Revolver Dirty Harry's gun! A great handgun and a worthy contender. Advantages:Most raw damage, Only one among 3 with a Scope, Very durable, Hand-loader round can be obtained without the Perk. Disadvantages: Expensive ammo, least amount of ammo, expensive to purchase and repair without jury rig. .45 Auto Pistol New guy on the block and considered one of the best! Advantages: In between The .44 and the 10mm with ammo, durability, damage, and price, Cheap Mods, Silence-able Disadvantages: Highest Repair Requirement for Super rounds, DLC purchase requirement, low ammo clip. Now looking through it would seem like it is pretty cut and dry. Why use 10mm rounds when the .45 auto Pistol is vastly more powerful and has many of the same benefits. While the .44 Magnum is far more durable, can be marksman ability and can deal out a lot of damage. And I say the 10mm Pistol still has a niche and that is the ammo count! 16 rounds is good imo. Thinking about the raw damage without perks or special rounds would end up looking like this. The .45 Auto Pistol will deal 203 Damage while the 10mm Pistol will deal 352 damage based purely on a single clip. Less reload time means more shooting and less stopping time. Give me your opinion if you disagree or even if you agree. I like all 3, but I'm curious how everyone else feels ^_^.