Not without any more specific informations.
What are your system specs, mods load order, version, the whole story.
Personally, I had a lot of CTDs when I didn't have enough VRAM.
I had a similar issue once and I'm sure it can be fixed by disabling window blinds and then updating directx. If this does not solve the whole thing then in addition service pack will need an update or a good tweak or two.