I'm interested in taking a few ideas given by the person who created Fallout Motor City and adding my own stuff to them. Detroit in the era that America could never culturally get past until the apocalypse was doing great, made military weapons and was a big front to the invasion of canada, and most importantly of all, had an influence in the United States quest for oil. So imagine if Vault tec was commissioned to make a large bunker with seed and information archives for the higher ups in the car, oil, and military industries? But instead of going into a coma and loosing a lot of resources like House did, they survived, came out 30-40 years later, and took control of the area?
While this idea would need to be handled carefully, I think it would be interesting to see what the corporations who ruined america would do if they could cut out the government middleman, and sortof have a shadowrun inspired corporate council consisting of the major corporations in the city that governs the area. I think it would be interesting to see what you could do with an anarcho-capitalist hellhole. There would still be a lot of abandoned places to explore on the non walled off parts the city, which are filled with misfortunate people trying to get by, druggies, gangs, and anti-council groups, some of which are terrorists. There are also a some good places to travel outside of the city. It would also be one of the few reasonable excuses to feasibly have a Fallout campaign where some areas are like Madmax and you can have car fights.