I've been playing a fairly all-around character with my highest skills being guns, lockpick, repair and speech. By level 18 or so (not even to vegas yet), I've bumped my guns skill up to around 75, but I still can't really tell a huge difference in my characters ability and I've probably only used VATS a few times in 40 hours of play because of it. Every time I tried it, it was showing worthless low accuracies from 20 feet away or more, and even if they were higher than 50% I was still missing every other shot if I tried to make multiple shots in VATS while crouched. Instead of using VATS, I've killed tons of stuff just sneaking in the hills and hitting crit headshots from long range with a silenced/scoped varmint rifle. Before I had the scope I was picking them off pretty easily with just the iron sights on the same rifle, and hitting every shot regardless of my character's guns skill. For close-up action I've been running and gunnin using a 44 mag revolver or the 10mm smg and I haven't run into much yet that I can't easily kill using this combination of stealth headshots to weaken them and the cowboy repeater or one of my 1-hand weapons to mop up. Since I picked up Boone and EDE, the sniping has gotten even more ridiculously effective. At this point, I'm wondering if the guns skill does much outside of VATS, and if anyone has been able to use VATS effectively for most of the game without taking a bunch of weapon specific VATS accuracy perks. As an avid FPS gamer, I don't mind that the shooting mechanics are consistent enough to allow me to blaze thru enemies on my own aim, but I figure I could spend my skill points more effectively if VATS is never effective and the guns skill doesn't really change much else.