I've never once played a game where being a good guy is harder and requires a lot more sacrifice. Because that's how it works in the real world, right? Right? If you're going to bother with karma in a game, make doing the right thing a lot more difficult and less rewarding than the wrong thing. People do bad things because it's lucrative or easier or safer than doing what's right. Not because they like seeing children enslaved or blowing up innocents. People instinctively don't play as bad guys because everyone knows that in every game ever you're rewarded a lot more and given a lot more opportunities for being a good guy. I'm sure it'll be the same in Vegas, sadly. And hey, maybe it'd be nice if doing the right thing for the right reasons actually does more damage in the long run. Like the canned Gizmo/Killian ending that was deemed too morally ambiguous for Fallout.