1UP posted an interview with Emil Pagliarulo called "Fallout 3 Afterthoughts".<blockquote>1UP: This could easily be a case of not being quite observant enough, but it seems like there are references to previous Fallouts, but not quite direct connections. For example, the Chosen One in Fallout 2 was supposedly a direct descendent of the Vault Dweller in Fallout. Is there a familial thread in Fallout 3 that I just didn't notice? And if so, was there a particular reason to not tie the Fallout 3 Vault Dweller to the previous games? Emil Pagliarulo: Looks like your observations were pretty dead-on, actually. It's true there are a few references to the characters, events, and locations of Fallout and Fallout 2, but they're mostly there as cool nods for fans that played those earlier PC games. And, yeah, there's no familial thread -- your character in Fallout 3 is not a descendent of the Vault Dweller in any way, shape, or form. It just didn't seem necessary. We wanted to tell our own story, without too many direct ties to what had come before. 1UP: Fallout had the Master and the Supermutant army as the main antagonists, and then Fallout 2 featured the Enclave. Why did you decide to feature the Enclave again, rather than introduce a new faction/antagonist? Was there ever a story draft that featured a different faction? EP: No, actually, there was never a draft of the story that featured a different faction -- it was always the Enclave. Why? For us, it just made so much sense. I mean, Fallout 2 established the Enclave as the remnant of the U.S. government, yet they'd set up shop on an oil rig off the coast of California. Wouldn't they eventually want to get back to Washington D.C. -- the nation's capital -- and set up shop again? Our game's set in D.C., so they were the perfect antagonists for us.</blockquote>There are a number of spoilers so I won't quote anything juicy, but there are among other things talk about the logic of the endgame, why there were so few Behemoths, and where you can find a special ghoul. Thanks to sonicblastoise.