Van Buren/FONV woulda shoulda been the natural culmination (and imo final conclusion) of a Fallout series
1. Pure post apo, but with signs of civilizations regrouping: Major city-states take shape, and begin trading with minor independent villages
2. City states form networks, large territories are organized, defended, patrolled. You see administrative centres and their satellites, you see organized military forces. You see serious rivalries between powers.
3. Fully fledged countries, complete with social tiers, fully rehabilitated urban centres (in particular in for example NCR heartland, not shown, but alluded to), standing armies, political systems in competition - humanity repaired for good and for bad.
The only way to continue the franchise from here would be to nuke everything again, which... would be a bit... forced? But I can def see that mindset, the want to nuke it all again, for that exact reason, if not only to make a statement.